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Insome studies, selected controls may be found subsequently to have missingkey information, and so may be excluded from the statistical analysis.Therefore, although researchers specify the target number of controls per case,the number actually recruited and analysed may be less. Theinspiratory muscle pressure needs to be suf?-cient to overcome three major mechanical prop-erties of the respiratory system: elastance (E)(to overcome tissue forces required to changethe lung volume (V)), resistance (R) (to over-come resistance to ?ow (V')), and inertance (I)(for acceleration (V'') of gas volumes). These airways are signi? cantly nar-rower in diameter than in adults

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